| Issue Date |
Song |
Artist |
| January 6 |
"Irreplaceable" |
Beyoncé |
| January 13 |
"Irreplaceable" |
Beyoncé |
| January 20 |
"Irreplaceable" |
Beyoncé |
| January 27 |
"Irreplaceable" |
Beyoncé |
| February 3 |
"Irreplaceable" |
Beyoncé |
| February 10 |
"You" |
Lloyd featuring Lil Wayne |
| February 17 |
"You" |
Lloyd featuring Lil Wayne |
| February 24 |
"You" |
Lloyd featuring Lil Wayne |
| March 3 |
"You" |
Lloyd featuring Lil Wayne |
| March 10 |
"This Is Why I'm Hot" |
Mims |
| March 17 |
"This Is Why I'm Hot" |
Mims |
| March 24 |
"This Is Why I'm Hot" |
Mims |
| March 31 |
"Don't Matter" |
Akon |
| April 7 |
"Don't Matter" |
Akon |
| April 14 |
"Don't Matter" |
Akon |
| April 21 |
"Buy U a Drank (Shawty Snappin')" |
T-Pain featuring Yung Joc |
| April 28 |
"Buy U a Drank (Shawty Snappin')" |
T-Pain featuring Yung Joc |
| May 5 |
"Buy U a Drank (Shawty Snappin')" |
T-Pain featuring Yung Joc |
| May 12 |
"Buy U a Drank (Shawty Snappin')" |
T-Pain featuring Yung Joc |
| May 19 |
"Buy U a Drank (Shawty Snappin')" |
T-Pain featuring Yung Joc |
| May 26 |
"Buy U a Drank (Shawty Snappin')" |
T-Pain featuring Yung Joc |
| June 2 |
"Buy U a Drank (Shawty Snappin')" |
T-Pain featuring Yung Joc |
| June 9 |
"Buy U a Drank (Shawty Snappin')" |
T-Pain featuring Yung Joc |
| June 16 |
"Buy U a Drank (Shawty Snappin')" |
T-Pain featuring Yung Joc |
| June 23 |
"Buy U a Drank (Shawty Snappin')" |
T-Pain featuring Yung Joc |
| June 30 |
"Party Like a Rockstar" |
Shop Boyz |
| July 7 |
"Beautiful Girls" |
Sean Kingston |
| July 14 |
"Beautiful Girls" |
Sean Kingston |
| July 21 |
"Beautiful Girls" |
Sean Kingston |
| July 28 |
"Beautiful Girls" |
Sean Kingston |
| August 4 |
"Bartender" |
T-Pain featuring Akon |
| August 11 |
"Bartender" |
T-Pain featuring Akon |
| August 18 |
"Make Me Better" |
Fabolous featuring Ne-Yo |
| August 25 |
"Make Me Better" |
Fabolous featuring Ne-Yo |
| September 1 |
"Make Me Better" |
Fabolous featuring Ne-Yo |
| September 8 |
"Shawty" |
Plies featuring T-Pain |
| September 15 |
"Shawty" |
Plies featuring T-Pain |
| September 22 |
"Crank That (Soulja Boy)" |
Soulja Boy Tell 'Em |
| September 29 |
"Crank That (Soulja Boy)" |
Soulja Boy Tell 'Em |
| October 6 |
"Crank That (Soulja Boy)" |
Soulja Boy Tell 'Em |
| October 13 |
"Crank That (Soulja Boy)" |
Soulja Boy Tell 'Em |
| October 20 |
"Crank That (Soulja Boy)" |
Soulja Boy Tell 'Em |
| October 27 |
"Crank That (Soulja Boy)" |
Soulja Boy Tell 'Em |
| November 3 |
"Kiss Kiss" |
Chris Brown featuring T-Pain |
| November 10 |
"Kiss Kiss" |
Chris Brown featuring T-Pain |
| November 17 |
"Kiss Kiss" |
Chris Brown featuring T-Pain |
| November 24 |
"Kiss Kiss" |
Chris Brown featuring T-Pain |
| December 1 |
"Kiss Kiss" |
Chris Brown featuring T-Pain |
| December 8 |
"Kiss Kiss" |
Chris Brown featuring T-Pain |
| December 15 |
"No One" |
Alicia Keys |
| December 22 |
"Low" |
Flo Rida featuring T-Pain |
| December 29 |
"Low" |
Flo Rida featuring T-Pain |